Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling
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چکیده
منابع مشابه
Age-related decline in reendothelialization capacity of human endothelial progenitor cells is restored by shear stress.
Aging is associated with dysfunction of endothelial progenitor cells (EPCs), and shear stress has a beneficial impact on EPC function; however, the effects of aging and shear stress on the endothelial repair capacity of EPCs after arterial injury have not been reported. Here we investigated the influence of aging and shear stress on the reendothelialization capacity of human EPCs and the relate...
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Intracellular protein degradation rates decrease with age in many tissues and organs. In cultured cells, chaperone-mediated autophagy, which is responsible for the selective degradation of cytosolic proteins in lysosomes, decreases with age. In this work we use lysosomes isolated from rat liver to analyze age-related changes in the levels and activities of the main components of chaperone-media...
متن کاملAge-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice
OBJECTIVE The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass. RESEARCH DESIGN AND METHODS We analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after short-term treatment with the glucagon-like peptide 1 (GLP-1) analog exendin-4, or after streptozotocin (STZ) administration. ...
متن کاملAge-dependent decline in fin regenerative capacity in the short-lived fish Nothobranchius furzeri
The potential to regenerate declines with age in a wide range of organisms. A popular model system to study the mechanisms of regeneration is the fin of teleost fish, which has the ability to fully regrow upon amputation. Here, we used the short-lived killifish Nothobranchius furzeri to analyse the impact of aging on fin regeneration in more detail. We observed that young fish were able to near...
متن کاملAge-dependent Decline in Beta Cell Proliferation Restricts the Capacity of Beta Cell Regeneration in Mice
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
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ژورنال
عنوان ژورنال: Nature Aging
سال: 2021
ISSN: 2662-8465
DOI: 10.1038/s43587-021-00041-7